[Plasma renin and aldosterone levels in obese and non-obese women with polycystic ovary syndrome].
نویسندگان
چکیده
OBJECTIVE To assess plasma renin and aldosterone levels in obese and non-obese women with polycystic ovary syndrome (PCOS). METHODS Obese women (body mass index [BMI]>30 kg/m2; group A, n=34) and non-obese women (BMI<25 kg/m2; group B, n=13) with PCOS were selected. The control group (groupC, n =47) consisted of age-matched women with regular menses and normal ultrasonographic ovaries. Luteinizing hormone, follicle-stimulating hormone, androstenedione, testosterone, sex hormone-binding globulin, serum glucose, insulin, renin, plasma renin activity, and aldosterone levels were measured. RESULTS Obese and non-obese women with PCOS had higher luteinizing hormone, follicle-stimulating hormone, androstenedione, testosterone, and insulin levels as compared to women in the control group (p<0.05). Women with PCOS had significantly higher renin levels (group A: 50.2±4.9 picoU/mL, group B: 39.9±2.7 picoU/mL, and group C: 24.6±2.6 picoU/mL), plasma renin activity (group A: 3.7±0.3 ng/mL/h, group B: 3.6±0.3 ng/mL/h, and group C: 2.2±0.4 ng/mL/h), and aldosterone levels (group A: 31.2±3.3 ng/dL, group B: 29.3±2.9 ng/dL, and group C: 22.2±3.9 ng/dL) as compared with controls. CONCLUSION Significant differences exist in plasma renin and aldosterone levels between obese and non-obese women as compared with polycystic ovary syndrome and normal controls.
منابع مشابه
Increased Total Renin Levels but Not Angiotensin-Converting Enzyme Activity in Obese Patients with Polycystic Ovary Syndrome
OBJECTIVE To investigate the renin-angiotensin-aldosterone system and angiotensin-converting enzyme (ACE) activity in patients with polycystic ovarian syndrome (PCOS). SUBJECTS AND METHODS In this case-control study, 41 obese (PCOS) women and 29 healthy controls, matched for age and body mass index, were enrolled. Anthropometric, metabolic, and hormonal patterns, including plasma aldosterone,...
متن کاملP-38: Comparison of Oxidative Stress and Antioxidative Status in non Obese Women with and without Polycystic Ovary Syndrome
متن کامل
P-205: Effects of Aerobic Exercise on Plasma Lipoproteins in Overweight and Obese Women with Polycystic Ovary Syndrome
Background: Polycystic ovary syndrome (PCOS) is one of the most frequent endocrine disorders. Obesity and anovulation in the women affected by this syndrome leads to a type of obesity that is followed by cardiovascular disease, hypertention and cholesterol and lipoprotein improper profiles. Changing the life style, e.g. increasing physical activities is the first approach in controlling PCOS Ma...
متن کاملP-220: A Two Purpose Use of Orlistat in Obese Women with Polycystic Ovary Syndrome: Weight Loss and Androgen Reduction
Background: Polycystic ovary syndrome (PCOS) is one of the most common endocrinopathies in young women. PCOS affects 6% and 8% of women in reproductive age. Hyperandrogenism is the hallmark of PCOS. Clinically, it is possible to observe hirsutism, acne, androgenic alopecia, and signs of virilization. Laboratory examination reveals increased androgen levels. Excessive androgen has an important r...
متن کاملAnalysis of CRP, Vitamin D and Metabolic Factors in Non-obese Patients with Polycystic Ovary Syndrome: a Cross Sectional Study in Imam Khomeini Hospital, Ahvaz
Background and Objectives: The polycystic ovary syndrome (PCOS) is one of the most common diseases diagnosed in women of childbearing age which is associated with increased risk of metabolic complications, including cardiovascular disease. Increasing C-reactive protein (CRP) as an inflammatory factor is common in these patients. In addition, vitamin D deficiency is quite common among females wi...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
- Endocrinologia y nutricion : organo de la Sociedad Espanola de Endocrinologia y Nutricion
دوره 59 1 شماره
صفحات -
تاریخ انتشار 2012